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In addition to MIFs immunogenic part, it's also been noted to Perform a very important job throughout neural embryonic advancement. Shen et al. (2013) demonstrated which the MIF pathway is required to the survival of statoacoustic ganglia and sensory hair cells inside a zebrafish product. Using knockdown with antisense oligonucleotide morpholinos (
Mice that deficiency Mif were being additional vulnerable to leishmaniasis and cysticercosis than wild-variety mice68,sixty nine. Phagocytosis of erythrocytes infected with Plasmodium chabaudi or uptake of malarial pigment (hemozoin) by macrophages induced the discharge of MIF MIF and host responses to other pathogens. In combination with bacteria